The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States

The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States

The American Journal of Human Genetics
Volume 96, Issue 1, 2015-01-08
Pages 37–53
DOI: 10.1016/j.ajhg.2014.11.010

Katarzyna Bryc, Research Fellow in Genetics (EXT)
Department of Genetics
Harvard Medical School, Boston, Massachusetts

Eric Y. Durand
23andMe, Inc., Mountain View, California

J. Michael Macpherson, Assistant Professor
School of Computational Sciences
Chapman University, Orange, California

David Reich, Professor of Genetics
Harvard Medical School, Boston, Massachusetts

Joanna L. Mountain, Senior Director of Research
23andMe, Inc., Mountain View, California

Over the past 500 years, North America has been the site of ongoing mixing of Native Americans, European settlers, and Africans (brought largely by the trans-Atlantic slave trade), shaping the early history of what became the United States. We studied the genetic ancestry of 5,269 self-described African Americans, 8,663 Latinos, and 148,789 European Americans who are 23andMe customers and show that the legacy of these historical interactions is visible in the genetic ancestry of present-day Americans. We document pervasive mixed ancestry and asymmetrical male and female ancestry contributions in all groups studied. We show that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US. This study sheds light on the fine-scale differences in ancestry within and across the United States and informs our understanding of the relationship between racial and ethnic identities and genetic ancestry.

Read the entire article here.

Tags: , , , , , , , , , ,